（1）甲氧滴滴涕对睾丸间质细胞发育和功能的影响机制。81102092。国家自然青年科学基金项目，2012-2014，1/7，结题。 （2）邻苯二甲酸酯复合染毒对睾丸间质细胞及间质干细胞的毒性机制研究。81373032。国家自然科学基金面上项目，2014-2017，3/10,结题。 （3）邻苯二甲酸酯类增塑剂对细胞色素酶影响的机制研究。Y20160539，温州市科技局，2017-2018，1/5，结题。 （4）中国汉族人群CYP2D6*10功能变异的分子机理及其人源化小鼠的构建与应用。LGF20H310001，浙江省公益技术研究计划；2020-2022；1/7。 （5）细胞色素P450酶2D6（CYP2D6）新变异体功能改变的分子机理与临床表型研究。81973397，国家自然面上项目；2020-2023；4/9。 |
3.发表论文 1）Yahui Wang, Qihui Kong, Huiyan Chai, Haidan Hu, Qianwen Zhang, Jianchang Qian, Bingbing Chen. Early Evaluation of the Interaction and Gender Differences in Combination of Apatinib and Metoprolol Using Humanized CYP2D6 Model. Chemical Research in Toxicology, 2025 Jan. 2）Qian J, Wang Y, Kong Q, Chai H, Hu H, Chen L, Hu L, Zhang Q, Hu G, Chen B. The metabolic profiles of endogenous and exogenous substances in a poor metabolizer of humanized CYP2D6 model. Eur J Pharm Sci. 2024 Sep 10. 3）Kong Q, Gao N, Wang Y, Hu G, Qian J, Chen B. Functional evaluation of cyclosporine metabolism by CYP3A4 variants and potential drug interactions. Front Pharmacol. 2023 Jan 6. 4）Bingbing Chen, Xiao-dan Zhang, Jian Wen, Bowen Zhang, Daoxing Chen, Shuanghu Wang, Jian-pin Cai, and Guo-xin Hu. Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism. Chemical research in toxicology. 2020.1. 5）Bingbing Chen, Xiaoxia Hu , Xiang Zhen , Guo-xin Hu. Effects of dibutyl phthalate and di(2-ethylhexyl) phthalate with their metabolites on CYP2C9*1 and CYP2C19*1 activities in vitro. Journal of Pharmaceutical and Biomedical Analysis. 2018.10.
|
