科研成果： 1. 科研项目 (1) 国家自然科学基金委员会, 联合基金项目, U22A20321, 基于γδT细胞功能亚群的肿瘤免疫微环境重塑与干预, 2023-01-01 至 2026-12-31, 255万元, 在研, 参与 (2) 国家自然科学基金委员会, 面上项目, 82273449, 雌激素重塑脂肪组织免疫微环境促进三阴性乳腺癌转移的机制研究, 2023-01-01 至 2026-12-31, 52万元, 在研, 参与 (3) 国家自然科学基金委员会, 青年科学基金项目（C类）[原青年科学基金项目], 82203616, 组织间充质基质细胞通过补体C3重塑乳腺癌肺转移前免疫微环境的机制研究, 2023-01-01 至 2025-12-31, 30万元, 在研,主持 (4) 国家自然科学基金委员会, 重点项目, 81930085, 炎症调控下间充质干细胞的异质性影响肿瘤发生发展的机制研究, 2020-01-01 至 2024-12-31, 297万元, 资助期满, 参与 2.所获成果（包括科研成果奖、专利、专著等） 3. 发表论文（具有代表性的5篇） (1) Zheng, Zhiyuan; Li, Ya-Nan; Jia, Shanfen; Zhu, Mengting; Cao, Lijuan; Tao, Min; Jiang, Jingting; Zhan, Shenghua; Chen, Yongjing; Gao, Ping-Jin; Hu, Weiguo; Wang, Ying; Shao, Changshun; Shi, Yufang ; Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3., Nature Communications, 2021, 12(1): 0-6202 (2) Yingqi Liang; Xiulan Lou; Yazhang Xu; Zhiyuan Zheng ; Protection of neutrophils by bone marrow mesenchymal stromal cells is enhanced by tumor-associated inflammatory cytokines, Frontiers in Immunology, 2024, 15（通讯作者 ) (3) Zhiyuan, Zheng; Shanfen, Jia; Changshun, Shao; Yufang, Shi ; Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells, Cell Death & Disease, 2020, 11(5): 0-326 (4) Zheng, Zhiyuan; Xu, Yazhang; Shi, Yufang; Shao, Changshun ; Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells, CELLULAR IMMUNOLOGY, 2022, 379: 1-7 (5) Fang, Jian-Hong; Zheng, Zhiyuan（共同一作）; Liu, Jin-Yu; Xie, Chen; Zhang, Zi-Jun; Zhuang, Shi-Mei ;Regulatory Role of the MicroRNA-29b-IL-6 Signaling in the Formation of Vascular Mimicry, Molecular Therapy - Nucleic Acids, 2017, 8: 90-100 |
