科研成果： 1. 科研项目 (1) 国家自然科学基金委员会, 青年科学基金项目 22007075, 抑制肿瘤血管形成铂(II)配合物的构筑及抗癌性质研究, 2021-01-01 至 2023-12-31, 24万元, 主持。 (2) 浙江省自然科学基金委员会, 探索项目, LQ20B010008, 铜配合物CPT8抗血管生成机理及体内抗肿瘤活性研究, 2020-01 至 2023-12, 9万元, 主持。 2. 发表论文（具有代表性的5篇） (1) Xiangchao Shi, Zhongyan Chen, Yanjun Wang, Zijian Guo, Xiaoyong Wang, Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells, Dalton Transactions, 2018, 47: 5049-5054. (2) Xiangchao Shi; Hongbao Fang, Yan Guo, Hao Yuan, Zijian Guo, Xiaoyong Wang, Anticancer copper complex with nucleus, mitochondrion and cyclooxygenase-2 as multiple targets, Journal of Inorganic Biochemistry, 2018, 190: 38-44. (3) Huixian Zheng, Chaoyi Hu, Yunyun Quan, Xiaoxia Ye, Xiangchao Shi, Zijian Guo, Xiaoyong Wang, A copper complex that combats triple negative breast cancer by restraining angiogenesis, Dalton Transactions, 2023, 52: 7626-7634. (4) Xiaomin Shen, Yue Peng, Zidong Yang, Renhao Li, Haixia Zhou, Xiaoxia Ye, Zhong Han, Xiangchao Shi, A monofunctional Pt(II) complex combats triple negative breast cancer by triggering lysosome-dependent cell death, Dalton Transactions, 2024, 53: 3808-3817. (5) Xiaomin Shen, Yue Peng, Haixia Zhou, Xiaoxia Ye, Zhong Han, Xiangchao Shi, A Pt (II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer, Journal of Inorganic Biochemistry, 2024, 253 (112502). |
