科研成果: 1. 科研项目 (1)主持浙江省自然科学基金,黄连解毒汤治疗AIDS蛋白酶抑制剂致动脉粥样硬化的实验研究 (2)主持浙江省基础公益研究计划,FRS2α介导的FGFR 信号在调节前列腺发育和组织稳态中的作用及机制研究 (3)参与国家973计划中医理论专项课题——“性、味结合归经”的温凉药性共同规律研究 (4)参与国家自然科学基金,双氢青蒿素抗结直肠癌及逆转5-FU耐药的分子机制 (5)参与国家自然科学基金,藤梨根通过调控Notch1信号转导通路治疗结直肠癌的机制研究 2. 所获成果(包括科研成果奖、专利、专著等) (1)新型bFGF/FGFR拮抗肽筛选及其在前列腺癌治疗中的作用机制研究,温州市科技局,温州市科技进步三等奖,第6完成人 (2)基于恶性肿瘤FGF信号分子靶标筛选新型拮抗肽的基础与应用研究,浙江省科技进步三等奖,第7完成人 (3)微囊化异种胰岛经人造血管移植治疗糖尿病的研究,浙江省医药卫生科技奖,三等奖,第7完成人 (4)高效微纳米载体的构建及其制剂开发,温州市科学技术进步奖,一等奖,第10完成人 (5)一种肌肤护理用丝素蛋白水凝胶及其制备方法专利(ZL201611047685.0) 3. 发表论文(具有代表性的5篇) (1)SHU-PING HU, YUAN ZHANG , ZHENG XIANG.Antioxidant Study of Three Curcuma Species and Screening of Antioxidant Components Using Stepwise Regression Analysis,Asian journal of chemistry.2014;26(19):6481-6486. (2)Shuping Hu, Min Zhao, Yiyuan Xi, Qiqi Mao, Xudong Zhou, Dawei Chen*, Pengcheng Yan*, Nontargeted Screening and Determination of Sulfonamides: A Dispersive Micro Solid-Phase Extraction Approach to the Analysis of Milk and Honey Samples Using Liquid Chromatography-High-Resolution Mass Spectrometry. J. Agric. Food Chem. 2017, 65(9), 1984-1991. (3)Shuping Hu,Min Zhao,Qiqi Mao,Chengyan Fang,Dawei Chen*,Pengcheng Yan*.Rapid one-step cleanup method to minimize matrix effects for residue analysis of alkaline pesticides in tea using liquid chromatography–high resolution mass spectrometry. Food Chemistry.2019, 299:125146. (4)Shuping Hu, Min Zhao, Zhongle Wang, Jiaying Yang, Dawei Chen*, Pengcheng Yan*,Development of a pH-dependent homogeneous liquid-liquid extraction by cold-induced phase separation in acetonitrile/water mixtures for determination of quinolone residues in animal-derived foods. Journal of Chromatography A. 2021,1649: 462235. (5)Hu SP,Ye BY,Li H,Yan PC,Chen DW,Zhao M.Enhanced selectivity for convenient extraction of acidic mycotoxins using a miniaturized centrifugal integrated cold-induced phase separation: Determination of fumonisins and ochratoxins in cereals as a proof-of-concept study.Food Chemistry.2024, 454:139715. |