陈高帜

教学育人成果：药学专业学位研究生精品课程核心成员

1.科研成果：

研究方向为“基于蛋白互作的药物发现”：以生命过程中的关键功能蛋白为靶点，探寻支撑蛋白功能的结构基础和分子机制并基于此结构基础和分子机制进行药物开发，为相关疾病的防治提供药物设计的靶点信息和候选药物。目前主持国家自然科学基金面上项目2项，青年项目1项，参与国家自然科学基金重点项目及国家自然科学基金国家（地区）合作与交流项目各1项。在Nature等杂志发表SCI论文35余篇，其中第一或通讯作者论文15篇，单篇最高影响因子69，单篇最高他引270余次。获得授权发明专利2项，申请3项。

2.所获成果（包括科研成果奖、专利、专著等）

（1）一类具有抗炎作用的咪唑并吡啶类化合物及其在制备抗炎药物中的应用，发明专利，ZL 2012 1 0484704.1，2015/11/25

（2）一种新型氮杂吲哚-2-酮类FGFR1抑制剂及其抗肿瘤活性发明专利，ZL 2014 1 0080869.1，2017/05/03

3.发表论文（具有代表性的5篇）

(1)Xuyong Zheng#; Chuchu Sun#; Qian Liu; Xiaoyao Lu; Lili Fu; Guang Liang; Xiuhua Zhang*; Gaozhi Chen*（通讯作者）. (2020) Compound LM9, a Novel Myd88 Inhibitor, Efficiently Mitigates Inflammatory responses and Fibrosis in Obesity-induced Cardiomyopathy,Acta Pharmacologica Sinica, 41(8): 1093-1101. (一区，IF=6.150，他引1)

(2)Gaozhi Chen#; Yuyan Bao#; Qiaoyou Weng; Yingxin Zhao; Xiaoyao Lu; Lili Fu; Lingfeng Chen; Zhiguo Liu; Xiaomin Zhang; Guang Liang*. (2020) Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers,Frontiers in Pharmacology, 10: 1533. (二区，IF=5.810，他引2)

(3)Gaozhi Chen#; Yang Liu#; Regina Goetz; Lili Fu; Seetharaman Jayaraman; Ming Chang Hu; Orson W Moe; Guang Liang; Xiaokun Li *. (2018) alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling,Nature, 553(7689): 461-466. (一区，IF=69.962，他引274)

(4)Gaozhi Chen #; Bing Xiao #; Lingfeng Chen #; Bin Bai; Yali Zhang; Zheng Xu; Lili Fu; Zhiguo Liu; Xiaokun Li *; Yunjie Zhao *; Guang Liang*. (2017) Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury,European Journal of Medicinal Chemistry, 139: 726-740. (一区，IF=6.514，他引7)

(5)Gaozhi Chen; Yali Zhang; Xing Liu; Qilu Fang; Zhe Wang; Lili Fu; Zhiguo Liu; Yi Wang; Yunjie Zhao; Xiaokun Li; Guang Liang*. (2016) Discovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury,Journal of Medicinal Chemistry, 59(6): 2436-2451. (一区，IF=7.446，他引33)