1.科研项目
(1)国家自然科学基金面上项目,柔性纳米脂质体介导脑源性神经营养因子经嗅区入脑发挥帕金森病模型大鼠多巴胺神经元保护作用实验研究,负责人。 (2)国家自然科学基金面上项目,改善骨细胞再生微环境的三维复合支撑骨架MSCs+dBECM-PGA+HA对于骨创伤的修复作用及其机制研究,负责人。 (3)国家自然科学基金面上项目,基于去细胞化组织基质和KGF构建的GF-ECM-HP温敏型水凝胶对子宫内膜损伤的修复作用及机制研究,负责人。 2.所获成果(包括科研成果奖、专利、专著等) (1)主编:去细胞生物支架,化学工业出版社,2022。 (2)主编:鼻腔药物制剂---基础与应用,化学工业出版社,2016。 (3)主编:超声介导药物靶向递送系统,化学工业出版社,2010。 3.发表论文(具有代表性的5篇) (1)Xu He-Lin, Mao Kai-Li, Lu Cui-Tao, Fan Zi-Liang, Yang Jing-Jing, Xu Jie, Chen Pian-Pian, ZhuGe De-Li, Shen Bi-Xin, Jin Bing-Hui, Xiao Jian, Zhao Ying-Zheng*. An injectable acellular matrix scaffold with absorbable permeable nanoparticles improves the therapeutic effects of docetaxel on glioblastoma. Biomaterials, 2016;107:44-60 (2)Zhao Ying-Zheng, Jiang Xi, Xiao Jian, Lin Qian, Yu Wen-Ze, Tian Fu-Rong, Mao Kai-Li, Yang Wei, Wong Ho Lun, Lu Cui-Tao. Using NGF heparin-poloxamer thermosensitive hydrogels to enhance the nerve regeneration for spinal cord injury. Acta Biomaterialia. 2016;29:71-80 (3)Zhao Ying-Zheng, Lin Qian, Wong Ho Lun, Shen Xiao-Tong, Yang Wei, Xu HL, Mao Kai-Li, Tian Fu-Rong, Yang Jing-Jing, Xu Jie, Xiao Jian, Lu Cui-Tao. Glioma-targeted therapy using Cilengitide nanoparticles combined with UTMD enhanced delivery. Journal of Controlled Release, 2016, 224:112-125 (4)Zhao Ying-Zheng, ZhuGe De-Li, Tong Meng-Qi, Lin Meng-Ting, Zheng Ya-Wen, Jiang Xue, Yang Wai-Geng, Yao Qing, Xiang Qi, Li Xiao-Kun, Xu He-Lin. Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation. Journal of Controlled Release, 2019;299:90-106 (5)Zhao Ying-Zheng, Lin Min, Lin Qian, Yang Wei, Yu Xi-Chong, Tian Fu-Rong, Mao Kai-Li, Yang Jing-Jing, Lu Cui-Tao, Wong Ho Lun. Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model. Journal of Controlled Release. 2016;224:165-175 |