科研成果: 1.科研项目 (1)基于色酮和马来酰亚胺的新型杂合体的设计、合成及其对急性肺损伤的药理活性研究,国家自然科学基金面上项目,63万,主持 (2)3-硫(硒)代吲哚的高效合成和抗炎活性研究,国家自然科学基金青年项目,27.5万,主持 (3)硒代马来酰亚胺类化合物的高效合成和抗骨质疏松活性研究,浙江省自然科学基金探索项目,10万,主持 (4)7-取代吲哚新的合成方法及其抗肿瘤活性的研究,浙江省自然科学基金青年项目,8万,主持 (5)温州医科大学第四批“优青培养工程”培养对象项目,80万,主持 2.所获成果(包括科研成果奖、专利、专著等) 3. 发表论文(具有代表性的5篇)
(1) Synthesis and Antiosteoporotic Characterization of Diselenyl Maleimides: Discovery of a Potent Agent for the Treatment of Osteoporosis by Targeting RANKL. Journal of Medicinal Chemistry, 2024, 67: 17226−17242. (最终通讯作者,Top一区) (2) Design, Synthesis, and Biological Evaluation of βTrifluoroethoxydimethyl Selenides as Potent Antiosteoporosis Agents. Journal of Medicinal Chemistry, 2024, 67: 7585−7602. (最终通讯作者,Top一区) (3) Metal-Free Radical [3 + 2] Annulation of Tetraalkylthiuram Disulfide with Alkynes/Alkenes: An Approach of Synthesizing 1,3-Dithiole and 1,3-Ditholane Derivatives, Organic Letters, 2024, 26, 3230−3234. (最终通讯作者,Top一区) (4) Metal-Free Oxidative Dearomatization−Alkoxylation/Acyloxylation of Indoles: Synthesis of 2Monosubstituted Indolin-3-ones, Organic Letters, 2023, 25: 7678−7682. (最终通讯作者,Top一区) (5) Design, Synthesis and Biological Evaluation of Novel Chromone-Maleimide Hybrids as Potent Anti-Inflammatory Agents against LPS-Induced Acute Lung Injury. Bioorganic Chemistry, 2022, 128:106049. (最终通讯作者,Top一区) |