科研成果: 1. 科研项目 1. 星形胶质细胞外泌体miRNA调控m6A RNA甲基化在神经干细胞命运决定和机体衰老中的作用及机制研究(32071030),国家自然科学基金委员会面上项目(59万),项目主持人,2021.01-2024.12 2.国家海外高层次引进人才青年项目启动基金,300万 3.福建省人才启动基金,40万 2.所获成果(包括科研成果奖、专利、专著等) 3. 发表论文(具有代表性的5篇) 1. Zhang Y#, Kim MS#, Jia B#, Yan J#, Zuniga-Hertz JP, Han C, Cai D. Hypothalamic stem cells control aging speed partly through exosomal miRNAs. Nature. 2017 Aug 3;548(7665):52-57. 2. Zhang Y, Reichel JM, Han C, Zuniga-Hertz JP, Cai D. Astrocytic process plasticity and IKKβ/NF-κB in central control of blood glucose, blood pressure and body weight. Cell Metabolism. 2017 May 2;25(5):1091-1102. 3. Zhang Y#, Guo H#, Zhang CS#, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism. 2013 Oct 1;18(4):546-55. 4. Lin H, Ye X, Chen W, Hong D, Liu L, Chen F, Sun N, Ye K, Hong J, Zhang Y, Lu F, Li L, Huang J. Modular organization of enhancer network provides transcriptional robustness in mammalian development. Nucleic Acids Res. 2025 Jan 11;53(2):gkae1323. 5. Jiang S, Chen H, Chen S, Chen N, Yang H, Duan Y, Ao S, Wang R, Wang X, Zhang Y*, Yuan J*. Genetically Encoded Biosensors for Constrained Biological Functions in Probiotic Escherichia coli Nissle. ACS Synth Biol. 2025 Jan 17;14(1):296-303. |