科研成果: 1. 科研项目 (1) 主持国家自然科学基金面上项目等国家级项目2项; (2) 主持省级杰出青年基金项目等省级或校级科研项目近10项。
2. 所获成果(包括科研成果奖、专利、专著等) (1) 省级自然科学二等奖 1项(参与); (2) 国家1类新药 临床批件 1项(参与); (3) 以第一发明人身份申请发明专利10余项,代表性授权专利如下所示: a. 含有二氢哒嗪结构的7‑氮杂吲哚类化合物及其应用,申请日:2016.12.28,授权日:2019.5.24; b. 2-氨甲酰基-4-芳杂吡啶类化合物的制备及应用,申请日:2017.10.23,授权日:2020.11.24; c. 一种化合物及其制备由Flt3/c-Met激酶高表达所引起疾病的药物的应用,申请日:2020.09.14,授权日:2021.10.29; d. 含三氮唑或喹啉酮结构的吡啶酰胺类化合物及其应用,申请日:2019 .11 .07,授权日:2023.02.09。
3. 发表论文(具有代表性的5篇) (1) Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway [J]. Journal of Medicinal Chemistry, 2023, 66, 12304-12323 (通讯作者,1区Top期刊); (2) Design, synthesis, and bio-evaluation of novel MyD88 inhibitor c17 against acute lung injury derived from the virtual screen [J]. Journal of Medicinal Chemistry, 2023, 66, 6938-6958 (通讯作者,1区Top期刊); (3) Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice [J]. European Journal of Medicinal Chemistry, 2024, 268, 116252 (通讯作者,1区Top期刊); (4) Novel O-benzylcinnamic acid derivative L26 Treats Acute Lung Injury in Mice by MD-2 [J]. European Journal of Medicinal Chemistry, 2023, 252, 115289 (通讯作者,1区Top期刊); (5) Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis [J]. European Journal of Medicinal Chemistry, 2023, 249, 115144 (通讯作者,1区Top期刊). |